Due to the fact might have been required, several sensitiveness analyses were performed to show you to definitely an apparent causal perception does not trust new picked analytical approach.17 18 Negative binomial regression was an attractive method for recurrent event modelling as it accommodates heterogeneity certainly patients. It assumes that each new member possess events predicated on their personal, certain experience speed owing to an arbitrary perception term and therefore may vary in respect so you're able to an excellent gamma shipping.19–21 An awful binomial regression design try therefore always obtain rates of your aftereffect of the chance items interesting towards the the outcome enjoy speed, in addition to all of the low-fatal and you will fatal Cv incidents. A downside out of negative binomial regression would be the fact it doesn't take care to experiences into account, which may bias the outcomes if you have irregular follow-up.20
Most sensitiveness analyses were did by using the Andersen-Gill and you may Wei-Lin-Weissfeld (WLW) habits,twenty-two 23 each other extensions of your own Cox proportional issues design so you're able to model perennial events. Regarding WLW model, individual clients are included in the danger set for experiences k regardless of whether he has knowledgeable experience k?step 1.